掌蹠膿疱症克服プロジェクト

    Research, case report, and clinical trial for PPP

    当該機構関係者による研究報告など

    A fluorescence imaging technique suggests that sweat leakage in the epidermis contributes to the pathomechanism of palmoplantar pustulosis
    Yatsuzuka K, Kawakami R, Niko Y, Tsuda T, Kameda K, Kohri N, Yoshida S, Shiraishi K, Muto J, Mori H, Fujisawa Y, Imamura T, Murakami M.
    Scientific Reports volume 14, Article number: 378 (2024)
    Open accessPublished: 03 January 2024
    Efficacy and Safety of Apremilast for the Treatment of Japanese Patients with Palmoplantar Pustulosis: Results from a Phase 2, Randomized, Placebo-Controlled Study.
    Terui T, Okubo Y, Kobayashi S, Sano S, Morita A, Imafuku S, Tada Y, Abe M, Yaguchi M, Uehara N, Handa T, Tanaka M, Zhang W, Paris M, Murakami M.
    Am J Clin Dermatol. 2023 Sep;24(5):837-847.
    doi: 10.1007/s40257-023-00788-2. Epub 2023 May 26.
    PMID: 37233897 Free PMC article. Clinical Trial.
    Spesolimab Efficacy and Safety in Patients with Moderate-to-Severe Palmoplantar Pustulosis: A Multicentre, Double-Blind, Randomised, Placebo-Controlled, Phase IIb, Dose-Finding Study.
    Burden AD, Bissonnette R, Navarini AA, Murakami M, Morita A, Haeufel T, Ye B, Baehner F, Terui T.
    Dermatol Ther (Heidelb). 2023 Oct;13(10):2279-2297.
    doi: 10.1007/s13555-023-01002-1. Epub 2023 Sep 20.
    PMID: 37731086 Free PMC article.
    New fluorescent three-dimensional and deep-imaging technique confirms a direct relationship between the acrosyringium and vesicles/pustules of palmoplantar pustulosis.
    Murakami M, Kawakami R, Niko Y, Tsuda T, Yatsuzuka K, Mori H, Imamura T, Sayama K.J Dermatol Sci. 2021 May;102(2):130-132. doi: 10.1016/j.jdermsci.2021.03.004. Epub 2021 Mar 19.
    Sustained efficacy and safety of guselkumab in patients with palmoplantar pustulosis through 1.5 years in a randomized phase 3 study.
    Okubo Y, Morishima H, Zheng R, Terui T.J Dermatol. 2021 Dec;48(12):1838-1853. doi: 10.1111/1346-8138.16132. Epub 2021 Aug 28.
    PMID: 34453358 Free PMC article. Clinical Trial.
    The microbiome of the "sterile" pustules in palmoplantar pustulosis.
    Masuda-Kuroki K, Murakami M, Tokunaga N, Kishibe M, Mori H, Utsunomiya R, Tsuda T, Shiraishi K, Tohyama M, Sayama K.
    Exp Dermatol. 2018 Dec;27(12):1372-1377.
    doi: 10.1111/exd.13791.
    PMID: 30281856
    Characteristics of Japanese patients with pustulotic arthro-osteitis associated with palmoplantar pustulosis: a multicenter study.
    Yamamoto T, Hiraiwa T, Tobita R, Hirano H, Masuda-Kuroki K, Ishii M, Murakami M, Terui T, Okubo Y.Int J Dermatol. 2020 Apr;59(4):441-444.
    doi: 10.1111/ijd.14788. Epub 2020 Jan 26.
    PMID: 31985054
    Palmoplantar pustulosis: Current understanding of disease definition and pathomechanism.
    Murakami M, Terui T.J Dermatol Sci. 2020 Apr;98(1):13-19.
    doi: 10.1016/j.jdermsci.2020.03.003. Epub 2020 Mar 14.
    PMID: 32201085 Review.
    Pompholyx vesicles contain small clusters of cells with high levels of hyaluronate resembling the pustulovesicles of palmoplantar pustulosis.
    Murakami M, Muto J, Masuda-Kuroki K, Tsuda T, Mori H, Utsunomiya R, Shiraishi K, Sayama K.
    Br J Dermatol. 2019 Dec;181(6):1325-1327.
    doi: 10.1111/bjd.18261. Epub 2019 Oct 9.
    PMID: 31254390 
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    Diagnostic histopathological features distinguishing palmoplantar pustulosis from pompholyx.
    Masuda-Kuroki K, Murakami M, Kishibe M, Kobayashi S, Okubo Y, Yamamoto T, Terui T, Sayama K.
    J Dermatol. 2019 May;46(5):399-408.
    doi: 10.1111/1346-8138.14850. Epub 2019 Mar 28.
    PMID: 30919463
    Efficacy and Safety of Guselkumab in Japanese Patients With Palmoplantar Pustulosis: A Phase 3 Randomized Clinical Trial.
    Terui T, Kobayashi S, Okubo Y, Murakami M, Zheng R, Morishima H, Goto R, Kimura T.
    JAMA Dermatol. 2019 Oct 1;155(10):1153-1161.　doi:10.1001/jamadermatol.2019.1394.
    PMID: 31268476 Free PMC article.
    Guselkumab for the treatment of palmoplantar pustulosis.
    Murakami M.Expert Opin Biol Ther. 2020 Aug;20(8):841-852.
    doi: 10.1080/14712598.2020.1760244. Epub 2020 May 12.
    PMID: 32321322 Review.
    TLN-58, an Additional hCAP18 Processing Form, Found in the Lesion Vesicle of Palmoplantar Pustulosis in the Skin.
    Murakami M, Kameda K, Tsumoto H, Tsuda T, Masuda K, Utsunomiya R, Mori H, Miura Y, Sayama K.
    J Invest Dermatol. 2017 Feb;137(2):322-331.
    doi: 10.1016/j.jid.2016.07.044. Epub 2016 Oct 19.
    PMID: 27771329
    Cefcapene Pivoxil Hydrochloride Is a Potentially New Treatment for Palmoplantar Pustulosis with Pustulotic Arthro-Osteitis.
    Murakami M, Masuda K, Utsunomiya R, Oda F, Namba C, Sayama K.
    Dermatology. 2015;231(4):304-11.
    doi: 10.1159/000439401. Epub 2015 Oct 7.
    PMID: 26440444
    Vesicular LL-37 contributes to inflammation of the lesional skin of palmoplantar pustulosis.
    Murakami M, Kaneko T, Nakatsuji T, Kameda K, Okazaki H, Dai X, Hanakawa Y, Tohyama M, Ishida-Yamamoto A, Sayama K.
    PLoS One. 2014 Oct 16;9(10):e110677.
    doi: 10.1371/journal.pone.0110677. eCollection 2014.
    PMID: 25330301 Free PMC article.
    Patients with palmoplantar pustulosis have increased IL-17 and IL-22 levels both in the lesion and serum.
    Murakami M, Hagforsen E, Morhenn V, Ishida-Yamamoto A, Iizuka H.
    Exp Dermatol. 2011 Oct;20(10):845-7.
    doi: 10.1111/j.1600-0625.2011.01325.x.
    Epub 2011 Jul 7.PMID: 21732985
    Acrosyringium is the main site of the vesicle/pustule formation in palmoplantar pustulosis.
    Murakami M, Ohtake T, Horibe Y, Ishida-Yamamoto A, Morhenn VB, Gallo RL, Iizuka H.
    J Invest Dermatol. 2010 Aug;130(8):2010-6.
    doi: 10.1038/jid.2010.87. Epub 2010 Apr 15.
    PMID: 20393482 Free article.
    見出し
    ここをクリックして表示したいテキストを入力してください。テキストは「右寄せ」「中央寄せ」「左寄せ」といった整列方向、「太字」「斜体」「下線」「取り消し線」、「文字サイズ」「文字色」「文字の背景色」など細かく編集することができます。
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